The Outcome of Multiple Slit on Plaque with Plication Technique for the Treatment of Peyronie's Disease

PURPOSE: To evaluate the postoperative outcome of the multiple slit on plaque plication technique for the treatment of Peyronie's disease. MATERIALS AND METHODS: We retrospectively evaluated 22 patients who underwent plaque incision with penile plication for the surgical treatment of Peyronie's disease, who had failed medical treatment between 2009 and 2014. Patients were grouped by preoperative degree of penile curvature into Group I: mild (n=5, 22.7%), Group II: moderate (n=11, 50.0%), and Group III: severe (n=6, 27.3%). After a thorough review of the medical records, we evaluated (a) the correction of the curvature; (b) sexual function; and (c) any penile shortening or other complications. RESULTS: The mean postoperative follow-up period was 39 months. Complete correction of the curvature was attained in 21 patients (95.5%). As an inevitable complication, minimal penile shortening (21). The most frequent complication was subcutaneous penile edema in three patients (13.6%), which was resolved within about 3 months following surgery. CONCLUSIONS: As a modified technique, multiple slit on plaque with plication is a simple, minimally-invasive and effective technique for correcting penile curvature regardless of curvature severity. The degree of penile curvature does not significantly predict the amount of penile length loss.

The Efficacy of Medical Treatment of Peyronie's Disease: Potassium Para-Aminobenzoate Monotherapy vs. Combination Therapy with Tamoxifen, L-Carnitine, and Phosphodiesterase Type 5 Inhibitor

PURPOSE: This study was designed to evaluate the efficacy of medical treatment of Peyronie's disease. MATERIALS AND METHODS: A total of 109 patients with Peyronie's disease who had been treated from January 2011 to December 2014 were retrospectively reviewed in this study. Forty-four patients (Group 1) were treated with 12 mg of potassium para-aminobenzoate daily. Sixty-five patients (Group 2) were treated with combination therapy: tamoxifen (20 mg) and acetyl-L-carnitine (300 mg) twice daily in addition to a phosphodiesterase type 5 inhibitor. Ability to perform sexual intercourse, pain during erection, size of plaque, and penile curvature angle were assessed. RESULTS: In Group 1, 30 of 44 patients (68.2%) discontinued treatment within 12 weeks, while 5 patients (7.7%) in Group 2 discontinued treatment. Pain during erection and plaque size were improved in both groups but showed no statistical difference due to the high dropout rate in Group 1. In both groups, penile curvature was improved, but demonstrated no statistical difference between the treatment groups. However, combination therapy demonstrated a better response rate in patients whose penile curvature angle was less than 30° (44.4% vs. 79.1%, p=0.048). The rate of successful sexual intercourse was significantly higher in Group 2 (42.8% vs. 78.3%, p=0.034). The number of patients who underwent surgical correction despite medical treatment was significantly higher in Group 1 (35.7% vs. 13.3%, p=0.048). CONCLUSIONS: Early medical combination therapy in Peyronie's disease may present better results in patients whose curvature angle is less than 30°.

Testicular Seminoma Incidentally Detected by Spermatic Cord Torsion / 대한남성과학회지

We recently encountered a very rare case of torsion of an intrascrotal testicular tumor in a 26-year-old male. Unlike the intra-abdominal undescended testis, intrascrotal spermatic cord torsion associated with a testicular tumor has rarely been reported. We write to report a case of intrascrotal spermatic cord torsion accompanied by a testicular tumor that had been overlooked preoperatively.

Effect of Potassium Aminobezoate in Oral Therapy for Peyronie's Disease: Preliminary Study / 대한남성과학회지

PURPOSE: To evaluate the effect and improvement of potassium aminobenzoate (500 mg Peyron capsule) in oral therapy for Peyronie's disease. MATERIALS AND METHODS: From February 2011 to September 2011, 31 patients with Peyronie's disease received potassium aminobezoate (500 mg Peyron capsules) and were divided into two groups. Group 1 (N=10) received potassium aminobezoate (500 mg Peyron capsule) 3 g four times daily without previous treatment of Peyronie's disease, while group 2 (N=21) received the same drug with previous treatment of Peyronie's disease (10 mg Tamoxifen +300 mg L-carnitine two times daily). Outcomes were assessed by subjective symptom change, pain relief, resolutions of the plaque, and curvature. RESULTS: After 3 months, there were no significant improvements in clinical outcomes of either group and among all the patients, 23 stopped taking potassium aminobezoate (23/31, 74%). The reasons for ceasing the therapy were gastrointestinal trouble (8/23, 35%), too many doses to take (7/23, 30%), ineffectiveness (6/23, 26%), and high price (2/23, 9%). CONCLUSIONS: Athough the etiology of Peyronie's disease has not been elucidated, potassium aminobenzoate in therapy of Peyronie's disease has been used. The use of this medication has the limitations of gastrointestinal trouble, ineffectiveness, too many doses, and high price. Further evaluations of the effect and appropriate dosing of potassium aminobenzoate are needed.

Effect of PDE5 Inhibitor in Nonsurgical Management of Peyronie's Disease: Preliminary Study / 대한남성과학회지

PURPOSE: This study was designed to evaluate the role of PDE5 inhibitors as combination therapy with conventional treatment of Peyronie's disease (PD). MATERIALS AND METHODS: From July 2007 to October 2010, 35 Patients were divided into two groups. Group I (N=14) received PDE5 inhibitors in addition to conventional treatment with tamoxifen and acetyl L-carnitine, while group II (N=21) received only conventional treatment. The follow-up duration was at least 12 weeks after the active therapy of PD. Outcomes were assessed by pain relief, successful attempts for sexual intercourse, resolution of the plaque and any occurring complications. RESULTS: In the efficacy of overall treatment of 35 patients, 94.3% patients experienced successful sexual intercourse, while 5.7% experienced pain on erection, and 25.7% showed a decrease in plaque size. The analysis of parameters before treatment showed no significant difference between groups in terms of successful attempt at sexual intercourse (p=0.583) and pain on erection (p=0.445). Furthermore, there was no difference between groups after treatment in terms of successful attempts at sexual intercourse (p=0.766), pain on erection (p=0.766) and change in plaque size (p=0.445). However, successful intercourse and pain relief after treatment showed significant change irrespective of groups (p<0.05). While the addition of a PDE5 inhibitor did not show any significant improvement in clinical outcome measures, the satisfaction of patient was higher in patients who received combination treatment (p=0.042). CONCLUSIONS: Although the effect of PDE5 inhibitor for pain relief, successful intercourse and resolution of plaque size was not significant, patients who received PDE5 inhibitors had a more satisfaction of treatment of PD. Further prospective studies on the effect of PDE5 inhibitor in PD will be needed.

A Study of Similarities Between Bloodstain Pattern Analysis and Fire Investigation In Point View of Event Analysis / 대한법의학회지

Crime scene reconstruction is the use of scientific methods, physical evidence, deductive and inductive reasoning and their interrelationships to gain explicit knowledge of the series of events that surround the commission of a crime. Event analysis is the method of crime scene reconstruction. As disciplines of crime scene reconstruction, bloodstain pattern analysis and fire investigation have many common points. Comparing bloodstain pattern analysis with fire investigation in point view of event analysis helps us to further understand crime scene reconstruction as well as bloodstain pattern analysis and fire investigation themselves. We study event analysis and apply it to cases and we seek similarities and differences between bloodstain pattern analysis and fire investigation by analyzing the methodology of both of them. In a fire scene, the point with the greatest damage is the point where the fire burned longest, which is likely to be the origin. In bloodstained scenes this approach is reversed. The greatest bloodshed point is most likely the ending point of the incident and is likely at or near the point where the bloodshed started. Above this, there are other similarities between them. Mastering the crime scene reconstruction requires long time hard training. Thus if the fire investigation experts or arson experts among crime scene investigators join the field of bloodstain pattern analysis(or reverse), then there will be many synergy effects to both of them.

The effects of early surfactant treatment and minimal ventilation on prevention of bronchopulmonary dysplasia in respiratory distress syndrome / 소아과

PURPOSE: Early surfactant treatment and minimal ventilation, bronchopulmonary dysplasia needed prolonged oxygen supplement is a problem. This study aimed to report the effects of early surfactant treatment and minimal ventilation on the prevention of bronchopulmonary dysplasia in respiratory distress syndrome. METHODS: We retrospectively studied 139 premature newborn infants (gestational age, 36 weeks; birth weight, 1,500 gm) admitted to the neonatal intensive care unit of Daegu Fatima Hospital between January 2001 and December 2006. We analyzed the occurrence of bronchopulmonary dysplasia with respect to ventilator care and surfactant treatment. RESULTS: The incidence of bronchopulmonary dysplasia was significantly higher with prolonged ventilator care, moderate to severe respiratory distress syndrome, and low Apgar score (P<0.001). Despite early surfactant treatment and minimal ventilation, mild bronchopulmonary dysplasia occurs in a considerable number of patients with mild respiratory distress syndrome. The patient group with low Apgar scores required ventilator care for a prolonged period (P=0.020). CONCLUSION: Early surfactant treatment and minimal ventilation shortens the duration of ventilator care; however, the preventive effe cts on bronchopulmonary dysplasia are limited. The refore, not only early surfactant treatment and minimal ventilation but also appropriate management in the delivery room is essential.

The Risk Factors for Persistence of Asthma Symptoms from Late Childhood to Early Adult Life: The Effects of Pulmonary Function and Bronchial Hyperresponsiveness / 소아알레르기및호흡기학회지

PURPOSE: We performed this study to evaluate the effect of pulmonary function and bronchial hyperresponsiveness (BHR) on the persistence of asthma symptoms from late childhood to early adult life. METHODS: One-hundred thirty-one children with asthma treated at our hospital during the past 10 years were divided into 2 groups according to the persistence of symptoms in early adult life: the persistent and remission groups. Information about symptoms, body mass index, serum ECP, serum IgE and skin test reactivity in late childhood were obtained and prebronchodilator FEV1, FEV1/FVC (expressed as % of predicted) and BHR to methacholine were measured in late childhood and early adult life, and compared the 2 groups. Results: The persistent group was accounted for 45.8% of the subjects and FEV1, FEV1/ FVC and BHR to methacholine in late childhood were associated with the persistence of symptoms. We found a positive correlation between FEV1 in late childhood and early adult.(r=0.250, P=0.013) Also we found a positive correlation between FEV1/FVC in late childhood and early adult.(r=0.285, P=0.018) BHR and FEV1% of 60% to 79% of late childhood were associated with BHR in early adult.(Odds ratio; 95% confidence interval=3.8; 1.7-8.7, 4.6; 1.0-20.2) Conclusion: Low pulmonary function and increased BHR in childhood asthma were associated with persistence of symptom, degree of pulmonary function and BHR in early adult life.

The effect of irradiation modes on polymerization and microleakage of composite resin / 대한치과보존학회지

The aim of this study was to investigate the effect of light irradiation modes on polymerization shrinkage, degree of cure and microleakage of a composite resin. VIP(TM) (Bisco Dental Products, Schaumburg, IL, USA) and Optilux 501(TM) (Demetron/Kerr, Danbury, CT, USA) were used for curing Filtek(TM) Z-250 (3M Dental Products, St. Paul., MN, USA) composite resin using following irradiation modes: VIP(TM) (Bisco) 200mW/cm2 (V2), 400mW/cm2 (V4), 600mW/cm2 (V6), Pulse-delay (200 mW/cm2 3 seconds, 5 minutes wait, 600mW/cm2 30seconds, VPD) and Optilux 501(TM) (Demetron/Kerr) C-mode (OC), R-mode (OR). Linear polymerization shrinkage of the composite specimens were measured using Linometer (R&B, Daejeon, Korea) for 90 seconds for V2, V4, V6, OC, OR groups and for up to 363 seconds for VPD group (n=10, each). Degree of conversion was measured using FTIR spectrometer (IFS 120 HR, Bruker Karlsruhe, Germany) at the bottom surface of 2 mm thick composite specimens. V2, V4, V6, OC groups were measured separately at five irradiation times (5, 10, 20, 40, 60 seconds) and OR, VPD groups were measured in the above mentioned irradiation modes (n=5, each). Microhardness was measured using Digital microhardness tester (FM7, Future-Tech Co., Tokyo, Japan) at the top and bottom surfaces of 2mm thick composite specimens after exposure to the same irradiation modes as the test of degree of conversion(n=3, each). For the microleakage test, class V cavities were prepared on the distal surface of the ninety extracted human third molars. The cavities were restored with one of the following irradiation modes: V2/60 seconds, V4/40 seconds, V6/30 seconds, VPD, OC and OR. Microleakage was assessed by dye penetration along enamel and dentin margins of cavities. Mean polymerization shrinkage, mean degree of conversion and mean microhardness values for all groups at each time were analyzed using one-way ANOVA and Duncan's multiple range test, and using chi-square test for microleakage values. The results were as follows: 1. Polymerization shrinkage was increased with higher light intensity in groups using VIP(TM) (Bisco): the highest with 600mW/cm2, followed by Pulse-delay, 400mW/cm2 and 200mW/cm2 groups. The degree of polymerization shrinkage was higher with Continuous mode than with Ramp mode in groups using Optilux 501(TM) (Demetron/Kerr). 2. Degree of conversion and microhardness values were higher with higher light intensity. The final degree of conversion was in the range of 44.7 to 54.98% and the final microhardness value in the range of 34.10 to 56.30. 3. Microleakage was greater in dentin margin than in enamel margin. Higher light intensity showed more microleakage in dentin margin in groups using VIP(TM) (Bisco). The micoleakage was the lowest with Continuous mode in enamel margin and with Ramp mode in dentin margin when Optilux 501(TM)(Demetron/Kerr) was used.

Study on masticatory pattern of adult having anterior cross bite / 대한치과교정학회지

mastication is basically regulated by central pattern regulator(CPG) of brain system target organ output from CPG is modulated by oral sensory feedback. anterior cross bite pattern infuluence the feedback mechanism and change muscle activity and jaw movement. .The purpose of this study was to investigate diffemce anterior cross bite group from normal group. the selected sample groups were 30 normal patient, 30 anterior cross bite patient. EMG and EGN of Biopak system were used for this study The following results were obtained 1. In resting state of mandible, anterior cross-bite showed the high r muscle activities in all the muscle.(exeeption:left digastric muscle) than normal group. 2. In clenching state, No significant difference in muscle activities of normal group and anterior cross bite group was noticed 3. In swallowing state Normal group showed the higher muscle activities in left and right masseter muscle, right posterior temporal muscle. 4. In maximum opening and closing velocity, normal group showed the higher value than anterior cross-bite. 5. In the mean value of the maximum operiing,the maximum anterior-posterior movement from centric-occlusion, the lateral deviation from centric-occclusion, normal group showed the higher value than anterior cross-bite group.